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The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multi-layered process of vertebrate tissue regeneration. DANIO-ReCODE will combine the multidisciplinary expertise of 15 research laboratories in EU and UK to: i) exploit the regenerative capacity of the highly tractable zebrafish (Danio rerio) model system to unravel the molecular mechanisms of heart, brain, and eye regeneration; ii) understand how regulation of regeneration in zebrafish compares to other vertebrates, including mammals; iii) identify vertebrate shared pathways for targeting regenerative therapies in humans, and iv) through the integration of state-of-the-art massively parallel sequencing technologies, genome editing, computational genomics, artificial intelligence (AI), and data visualisation, generate next generation regulatory genomics resources, which will enhance the understanding of vertebrate regenerative processes, while providing new avenues for the repair or replacement of damaged or diseased cells, organs, or tissues.

Project title

DC1: cis-regulation during in vivo and in vitro organ development

DC2: Epigenetic interpretation of cell extrinsic mechanical properties of zebrafish eye organoids

DC3: Deciphering Molecular Mechanisms Underlying Successful Brain Regeneration in Zebrafish

DC4: Characterization of cis-regulatory networks in cardiac muscle de- and re-differentiation in heart regeneration

DC5: Promoter architecture and usage during zebrafish, axolotl, and mouse regenerative neurogenesis

DC6: Novel approaches to integrate genomic information from model organisms into human regulatory landscapes

DC7: Identifying the gene regulatory code for regeneration

DC8: Deciphering molecular programs regulating the reversible quiescence of mammalian neural stem cells

DC9: Conversational AI for exploring complex data in tissue regeneration research

DC10: An innovative genome browser to integrate time-resolved single-cell and bulk-cell data

DC11: Novel solutions for combining multi-omics embeddings and regulatory network visualisations

DC12: Multi-omic characterisation of transcription initiation regulation in development and injury response

DC13: Annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury

DC14: Comparative epigenomics of vertebrate regeneration

DC15: Cross-species cell atlases for regeneration

For general inquiries, please contact daniorecode@csic.es 

Project

Objetives

The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multi-layered process of vertebrate tissue regeneration. DANIO-ReCODE will combine the multidisciplinary expertise of 15 research laboratories in EU and UK to: i) exploit the regenerative capacity of the highly tractable zebrafish (Danio rerio) model system to unravel the molecular mechanisms of heart, brain, and eye regeneration; ii) understand how regulation of regeneration in zebrafish compares to other vertebrates, including mammals; iii) identify vertebrate shared pathways for targeting regenerative therapies in humans, and iv) through the integration of state-of-the-art massively parallel sequencing technologies, genome editing, computational genomics, artificial intelligence (AI), and data visualisation, generate next generation regulatory genomics resources, which will enhance the understanding of vertebrate regenerative processes, while providing new avenues for the repair or replacement of damaged or diseased cells, organs, or tissues.

This project has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie. Grant Agreement No 101169349.

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