
About
The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multi-layered process of vertebrate tissue regeneration. DANIO-ReCODE will combine the multidisciplinary expertise of 15 research laboratories in EU and UK to: i) exploit the regenerative capacity of the highly tractable zebrafish (Danio rerio) model system to unravel the molecular mechanisms of heart, brain, and eye regeneration; ii) understand how regulation of regeneration in zebrafish compares to other vertebrates, including mammals; iii) identify vertebrate shared pathways for targeting regenerative therapies in humans, and iv) through the integration of state-of-the-art massively parallel sequencing technologies, genome editing, computational genomics, artificial intelligence (AI), and data visualisation, generate next generation regulatory genomics resources, which will enhance the understanding of vertebrate regenerative processes, while providing new avenues for the repair or replacement of damaged or diseased cells, organs, or tissues.
Project title
DC1: cis-regulation during in vivo and in vitro organ development
DC2: Epigenetic interpretation of cell extrinsic mechanical properties of zebrafish eye organoids
DC3: Deciphering Molecular Mechanisms Underlying Successful Brain Regeneration in Zebrafish
DC5: Promoter architecture and usage during zebrafish, axolotl, and mouse regenerative neurogenesis
DC7: Identifying the gene regulatory code for regeneration
DC9: Conversational AI for exploring complex data in tissue regeneration research
DC10: An innovative genome browser to integrate time-resolved single-cell and bulk-cell data
DC11: Novel solutions for combining multi-omics embeddings and regulatory network visualisations
DC14: Comparative epigenomics of vertebrate regeneration
DC15: Cross-species cell atlases for regeneration
For general inquiries, please contact daniorecode@csic.es