Objetives
The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multi-layered process of vertebrate tissue regeneration. DANIO-ReCODE will combine the multidisciplinary expertise of 15 research laboratories in EU and UK to: i) exploit the regenerative capacity of the highly tractable zebrafish (Danio rerio) model system to unravel the molecular mechanisms of heart, brain, and eye regeneration; ii) understand how regulation of regeneration in zebrafish compares to other vertebrates, including mammals; iii) identify vertebrate shared pathways for targeting regenerative therapies in humans, and iv) through the integration of state-of-the-art massively parallel sequencing technologies, genome editing, computational genomics, artificial intelligence (AI), and data visualisation, generate next generation regulatory genomics resources, which will enhance the understanding of vertebrate regenerative processes, while providing new avenues for the repair or replacement of damaged or diseased cells, organs, or tissues.
This project has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie. Grant Agreement No 101169349.